Personnel Information

写真a

Tokuraku Kiyotaka


Affiliation centers1, etc

The Center for Creative Collaboration

The master's program in charge

Division of Sustainable and Environmental Engineering

The doctoral program in charge

Division of Engineering

The department in charge

Department of Sciences and Informatics

Job title

Associate Professor

E-mail Address

E-mail address

Research field 【 display / non-display

  • Functional biochemistry

  • Biophysics

  • Chemical biology

Keywords for Research Field 【 display / non-display

  • amyloid

  • Alzheimer's Disease

  • Self-organization

  • Quantum dot

  • Cytoskeleton

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Research themes 【 display / non-display

  • Imaging of amyloid-beta peptide aggregation using a quantum dot-based nanoprobe

    amyloid,Quantum dot,Imaging,2008 ~ 2018

  • Functional analysis of microtubule-associated protein 4

    Microtubule,Microtubule-associated protein,Cytoskeleton,1996 ~ 2018

  • Conformation polymorphism and function of actin filament

    Actin,Myosin,Cofilin,1999 ~ 2018

Graduate school・Graduate course, etc. 【 display / non-display

  • University of Tsukuba

    1996.03,Master's Course,Graduate School, Division of Biosystem,バイオシステム専攻,Completed,Japan

  • Kyushu Institute of Technology

    1999.03,Doctoral program,Graduate School, Division of Information Engineering,Department of information science,Completed,Japan

Graduate school・major, etc. 【 display / non-display

  • Miyakonojo National College of Technology

    1992.03,その他,工業化学科,Graduate

  • Kyushu Institute of Technology

    1994.03,Faculty of Computer Science and Systems Engineering,生物化学システム工学科,Graduate,日本

Degree 【 display / non-display

  • PhD

    Study on the function of the pro-rich region in microtubule-associated protein 4

Academic Society 【 display / non-display

  • The Japanese Biochemical Society

  • The Zoological Society of Japan

  • The Biophysical Society of Japan

  • American Society for Biochemistry and Molecular Biology

  • Japan Society for Bioscience, Biotechnology, and Agrochemistry

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Academic prize 【 display / non-display

  • Outstanding Poster Award

    2014.11.10,The 5th Forum on Studies of the Environmental and Public Health Issues in the Asian Mega-cities (EPAM 2014)

  • Best Presentation Award

    2016.09.01,EPAM2016

  • Best Presentation Award

    2016.09.01,EPAM2016

  • Poster Award

    2017.10.24,The 10th International Conference and Exhibition on Nutraceuticals & Functional Foods

 

タンパク質の自己集合による機能創成

Purpose of Research

タンパク質が自己集合することにより創発される機能を解明する。

Summary of Research

アクチンフィラメント、微小管、アミロイドなど、繊維を形成するタンパク質について、その機能を調べる。
Research Content

Features / Benefits of Research

1.Point of research 2.Research of novelty
  • 自己集合制御機構の解明
  • アミロイドβ凝集阻害物質の微量ハイスループットスクリーニング(MSHTS)法を開発
3.Primacy of Technology 4.Situation of patent-related
  • 数μLの微量サンプル量で多数のサンプルのAβ凝集阻害活性を効率的に評価できる。また夾雑物を多く含む粗抽出物や食品の評価も可能。
 

Books 【 display / non-display

  • BIO Clinica

    徳樂清孝、上井幸司,北隆館,量子ドットを用いたAβ凝集阻害物質の微量ハイスループットスクリーニング法,(p.114),2016.04,0919-8237

  • NETT91

    徳樂清孝,北海道東北地域経済総合研究所,シソがつないだ地域連携 〜室蘭工業大学と北海道白糠町の包括連携協定による抗認知症物質の探索〜,(p.82),2016.01

  • Recent Research Development in Biochemistry

    Kiyotaka Tokuraku, Miho Katsuki, and Susumu Kotani,Research Signpost,Structural and Functional Analyses of Microtubule-associated Protein 4,(p.391),2002,81-7736-155-4

  • 生体の科学 モチーフ・ドメインリスト

    徳楽清孝,医学書院,チューブリン結合モチーフ,微小管結合(リピート)ドメイン,(p.164),2001.10

Papers 【 display / non-display

  • Comparison of AA amyloid fibril morphology and serum amyloid A gene sequence in five animal species

    Xuguang Lin, Masahiro Kuragano, Kenichi Watanabe, Kiyotaka Tokuraku,Veterinary Pathology,Article Number:in press,2020.11

  • Microtubule elongation along actin filaments induced by microtubule-associated protein 4 contributes to the formation of cellular protrusions

    Chihiro Doki, Kohei Nishida, Shoma Saito, Miyuki Shiga, Hikaru Makihara, Ayumu Kuramoto, Masahiro Kuragano, Motohiro Nozumi, Michihiro Igarashi, Hiroyuki Nakagawa, Susumu Kotani, Kiyotaka Tokuraku,Journal of Biochemistry,vol.168,(p.295 ~ 303),2020.09

  • Daurichromenic Acid from the Chinese Traditional Medicinal Plant Rhododendron dauricum Inhibits Sphingomyelin Synthase and Aβ Aggregation

    Hadya Virupaksha Deepak, Mahadeva M. Swamy, Yuta Murai, Yoshiko Suga, Masaki Anetai, Takuro Yo, Masahiro Kuragano, Koji Uwai, Kiyotaka Tokuraku, Kenji Monde,Molecules,vol.25,Article Number:4077,2020.09

  • Dietary intake of rosmarinic acid increases serum inhibitory activity in amyloid A aggregation and suppresses deposition in the organs of mice

    Xuguang Lin, Kenichi Watanabe, Masahiro Kuragano, Yukina Kurotaki, Ushio Nakanishi, Kiyotaka Tokuraku,International Journal of Molecular Science,vol.21,Article Number:6031,2020.08

  • Mechanical Stimulation-Induced Orientation of Gliding Microtubules in Confined Microwells

    Inoue Daisuke, Kabir Arif Md. Rashedul, Tokuraku Kiyotaka, Sada Kazuki, Kakugo Akira,ADVANCED MATERIALS INTERFACES,vol.7,(13),Article Number:1902013,2020.07

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International conference proceedings 【 display / non-display

  • Biological evaluation of disinfecting effect of slaked lime under the situation of "standby disinfection"

    Shinji Matsuzaki, Kento Azuma, Xuguang Lin, Masahiro Kuragano, Koji Uwai, Shinya Yamanaka, Kiyotaka Tokuraku,Joint Seminar on Environmental Science and Disaster Mitigation Research 2020,(p.18 ~ 19),2020.03,Muroran

  • Aβ-aggregation inhibitors isolated from willow (Salix sachalinensis)

    aro Imamaeda, Hiroyuki Kumeta, Masahiro Kuragano, Chigusa Seki, Hiroto Nakano, Tomoyasu Aizawa, Kiyotaka Tokuraku, Koji Uwai,Joint Seminar on Environmental Science and Disaster Mitigation Research 2020,(p.100 ~ 101),2020.03,Muroran

  • Microtubule-associated protein 4 promotes cellular process formation by binding to both actin filament and microtubule

    Kohei Nishida, Masahiro Kuragano, Chihiro Doki, Susumu Kotani, Kiyotaka Tokuraku,Joint Seminar on Environmental Science and Disaster Mitigation Research 2020,(p.90 ~ 91),2020.03,Muroran

  • Evaluation of serum amyloid A aggregation in in vitro and in vivo using a quantum dot nanoprobe

    Xuguang Lin, Masahiro Kuragano, Kenichi Watanabe, Kiyotaka Tokuraku,Joint Seminar on Environmental Science and Disaster Mitigation Research 2020,(p.92 ~ 93),2020.03,Muroran

  • Time-lapse observation of cooperative binding between fimbrin and actin filament by fluorescence microscopy

    Naoki Hosokawa, Masahiro Kuragano, Keitaro Shibata, Taro Q.P. Uyeda, Kiyotaka Tokuraku,Joint Seminar on Environmental Science and Disaster Mitigation Research 2020,(p.46 ~ 47),2020.03,Muroran

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Editorial and Commentary 【 display / non-display

  • 北海道天然資源を利用して地域・世界を救う 〜アオジソの抗認知症機能性食品としての可能性〜

    上井幸司、徳樂清孝,グリーンテクノ情報,vol.15,(p.9 ~ 13),2019.06

Research reports 【 display / non-display

  • 量子ドットナノプローブを用いたアミロイド凝集過程のリアルタイムイメージング技術とその活用

    徳樂清孝、上井幸司,第54回粉体に関する討論会講演論文集,(p.136 ~ 140),2016.09

  • 蛍光性半導体ナノ結晶を用いた高アルツハイマー剤の微量探索システムの開発

    徳樂清孝,モ・ルラン,(59),(p.6 ~ 8),2016.04

  • 量子ドットナノプローブを用いた香辛料からのβ-アミロイド凝集阻害物質の網羅的スクリーニング

    徳樂清孝,山崎香辛料振興財団 平成23年度助成金交付申請書,2012.04

  • 量子ドットナノプローブを用いた香辛料からのβ-アミロイド凝集阻害物質の網羅的スクリーニングについて

    徳樂清孝,Letters from MuroranIT,vol.43,2012.01

  • 共焦点顕微鏡を用いた微小管の単分子蛍光映像解析によるアルツハイマー病発症メカニズムの解明

    徳樂清孝,平成19年度「国立高等専門学校機構在外研究員」実績報告書,2009.04

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Presentaion at conference, meeting, etc. 【 display / non-display

  • 消毒効果が見える!まきやすい!長持ちする!粒状消石灰

    山中真也, 上井幸司, 徳樂清孝, 中野浩幸, 中野誠一, 西川雄亮, 野村孝義, 澁谷直樹, 矢嶋健太, 山田雄大, 片山貴志,アグリビジネス創出フェア2020,農林水産省,展示用資料,2020.11.11,オンライン開催

  • Real time imaging of amyloid aggregation using quantum dot nanoprobe and microliter-scale high-throughput screening system for aggregation inhibitors

    Kiyotaka Tokuraku,International Webinar series,Kasturba Medical College,Recent trends in Neuroscience Research,2020.10.24,Webinar,India

  • カロテノイド同時定量法の開発とそのトマトへの適用

    岡西隼、佐藤敦哉、徳欒清孝、上井幸司,日本食品化学学会第26回総会・学術大会,日本食品化学学会第26回総会・学術大会講演要旨集,(p.29),2020.08

  • 食品エキスのアミロイドβ凝集阻害および細胞毒性緩和能の網羅的評価

    山岸愛永、佐藤敦哉、倉賀野正弘、上井幸司、徳樂清孝,日本食品化学学会第26回総会・学術大会,日本食品化学学会第26回総会・学術大会講演要旨集,(p.27),2020.08

  • STD-NMR法による植物抽出エキスのアミロイドβ結合スクリーニング

    上井幸司、久米田博之、今前田大朗、倉賀野正弘、関千草、中野博人、相沢智康、徳樂清孝,日本薬学会第140年会,日本薬学会第140年会講演要旨集,(p.28Q-pm136),2020.03.28,京都,日本

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Patent and utility model acquisition 【 display / non-display

  • 消毒剤

    日本,特願2015-047017,特開2016-166150,特許第6633831号

  • 常温溶融塩を用いた電気泳動法による希土類およびアルカリ土類元素の濃縮方法及び回収装置

    日本,特願2004-76644,特開2005-264209,特許第4242313号

  • DISINFECTANT

    ベトナム,1-2017-04016

  • DISINFECTANT

    中国,201680014300.2,CN107708423A

  • 消毒剤

    日本,特願2016-176927,特開2018-039767

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Class subject in charge 【 display / non-display

  • 生化学B(後半8週)

    2020,Department

  • 基礎生物学(A・B・Cクラス)

    2020,Department

  • 生物工学実験(応化・バイオ)

    2020,Department

  • 蛋白質化学特論

    2020,Master's program

  • 環境創生工学特論

    2020,Master's program

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International research cooperation activities 【 display / non-display

  • Joint seminar on environmental and biological chemistry

    中国,内蒙古師範大学,2019.07