論文 - 上井　幸司

1. 農場における植物の葉の蛍光分光測定装置

   中西陽菜、上井幸司、飯森俊文，分光研究，73巻，(頁 135 ～ 137)，2025年02月

   

2. On-Site Evaluation of Constituent Content and Functionality of Perilla frutescens var. crispa Using Fluorescence Spectra

   Hidemichi Sano, Satoru Kawaguchi, Toshifumi Iimori , Masahiro Kuragano , Kiyotaka Tokuraku and Koji Uwai，Molecules，28巻，Article Number:7199，2023年10月

   

3. New boro amino amide organocatalysts for asymmetric cross aldol reaction of ketones with carbonyl compounds

   Zubeda Begum, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita and Hiroto Nakano，RSC Advances，13巻，2号，(頁 888 ～ 894)，2023年01月

   

4. Thiourea fused g-amino alcohol organocatalysts for asymmetric Mannich reaction of b-keto active methylene compounds with imines

   Miku Nomura, Zubeda Begum, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita and Hiroto Nakano，RSC Advances，13巻，6号，(頁 3715 ～ 3722)，2023年01月

   

5. Cultivation Factors That Affect Amyloid-β Aggregation Inhibitory Activity in Perilla frutescens var. crispa

   Keiya Shimamori, Tomohiko Nambu, Daiki Kawamata, Masahiro Kuragano, Naoki Nishishita, Toshifumi Iimori, Shinya Yamanaka, Koji Uwai, Kiyotaka Tokuraku，Foods，12巻，Article Number:486，2023年01月

   

6. Microwave-assisted synthesis and formation mechanism of fluorescent carbon dots from starch

   Hisahiko Shibata, Mina Abe, Kazuya Sato, Koji Uwai, Kiyotaka Tokuraku, Toshifumi Iimori，Carbohydrate Polymer Technologies and Applications，3巻，Article Number:100218，2022年06月

   

7. Chemical analysis of amyloid β aggregation inhibitors derived from Geranium thunbergii

   Kenji Kubo, Hikaru Watanabe, Hiroyuki Kumeta, Tomoyasu Aizawa, Chigusa Seki, Hiroto Nakano, Kiyotaka Tokuraku, Koji Uwai，Bioorganic & Medicinal Chemistry，68巻，Article Number:116840，2022年05月

   

8. New small gamma-turn type N-primary amino terminal tripeptide organocatalyst for solvent-free asymmetric aldol reaction of various ketones with aldehydes

   Rajkumar Thiyagarajan, Zubeda Begum, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano，RSC Advances，11巻，61号，(頁 38925 ～ 38932)，2021年12月

   

9. Simple amino silyl ether organocatalyst for asymmetric hetero Diels–Alder reaction of isatins with enones

   Perumalsamy Parasuraman, Divakar Ganesan, Zubeda Begum, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano，CHIRALITY，33巻，8号，(頁 454 ～ 464)，2021年08月

   

10. Farm use of calcium hydroxide as an effective barrier against pathogens

    Shinji Matsuzaki, Kento Azuma, Xuguang Lin, Masahiro Kuragano, Koji Uwai, Shinya Yamanaka, Kiyotaka Tokuraku，Scientific Reports，11巻，Article Number:7941，2021年04月

    

11. Simple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes

    Zubeda Begum, Haruka Sannabe, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita and Hiroto Nakano，RSC Advances，1号，(頁 203 ～ 209)，2020年12月

    

12. Daurichromenic Acid from the Chinese Traditional Medicinal Plant Rhododendron dauricum Inhibits Sphingomyelin Synthase and Aβ Aggregation

    Hadya Virupaksha Deepak, Mahadeva M. Swamy, Yuta Murai, Yoshiko Suga, Masaki Anetai, Takuro Yo, Masahiro Kuragano, Koji Uwai, Kiyotaka Tokuraku, Kenji Monde，Molecules，25巻，Article Number:4077，2020年09月

    

13. Evaluation of amyloid β42 aggregation inhibitory activity of commercial dressings by a microliter-scale high-throughput screening system using quantum-dot nanoprobes

    Masahiro Kuragano, Wataru Yoshinari, Xuguang Lin, Keiya Shimamori, Koji Uwai and Kiyotaka Tokuraku，Foods，9巻，Article Number:825，2020年06月

    

14. Design of calcium hydroxide–based granules for livestock sanitation

    Shinya Yamanaka, Shuya Hirano, Koji Uwai, Kiyotaka Tokuraku，Case Studies in Chemical and Environmental Engineering，2巻，Article Number:100005，2020年04月

    

15. Simple organocatalyst component system for asymmetric hetero Diels–Alder reaction of isatins with enones

    Perumalsamy Parasuraman, Zubeda Begum, Madhu Chennapuram, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita and Hiroto Nakano，RSC Advances，10号，(頁 17486 ～ 17491)，2020年04月

    

16. Sugar Based γ-Amino Alcohol Organocatalyst for Asymmetric Michael Addition of β-Keto Esters with Nitroolefins

    Divakar Ganesan, Madhu Chennapuram, Zubeda Begum, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita, and Hiroto Nakano，Heterocycles，98巻，11号，(頁 1536 ～ 1545)，2019年11月

    

17. 2-Azanorbornane-Based Amino Alcohol Organocatalysts for Asymmetric Michael Reaction of β-Keto Esters with Nitroolefins

    Rei Togashi, Madhu Chennapuram, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano，European Journal of Organic Chemistry，2019巻，24号，(頁 3882 ～ 3889)，2019年06月

    

18. An automated microliter-scale high-throughput screening system (MSHTS) for real-time monitoring of protein aggregation using quantum-dot nanoprobes

    Sasaki, R., Tainaka, R., Ando, Y., Hashi, Y., Virupaksha D.H., Suga, Y., Murai, Y, Anetai, M., Monde, K., Ota, K., Ito, I., Kikuchi, H., Oshima, Y., Endo, Y., Nakao, H., Sakono, M., Uwai, K., and Tokuraku，Scientific Reports，9巻，Article Number:2587，2019年02月

    

19. Amino Amide Organocatalysts for Asymmetric Michael Addition of β-Keto Esters with β-Nitroolefins

    Isiaka A. Owolabi, Madhu Chennapuram, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano，BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN，92巻，3号，(頁 696 ～ 701)，2019年01月

    

20. A new type of amino amide organocatalyzed enantioselective crossed aldol reaction of ketones with aromatic aldehydes

    Isiaka A. Owolabi, U.V.Subba Reddy, Madhu Chennapuram, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano，Tetrahedron，74巻，36号，(頁 4705 ～ 4711)，2018年09月

    

21. New Hybrid-type Squaramide-Fused Amino Alcohol Organocatalyst for Enantioselective Domino Michael Addition/Cyclization Reaction of Oxoindolines with Cyclic 1,3-Diketones

    Madhu Chennapuram, Isiaka Alade Owolabi, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita, and Hiroto Nakano，ACS OMEGA，3巻，9号，(頁 11718 ～ 11726)，2018年09月

    

22. Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction

    Yuta Tsukamoto, Sotaro Ikeda, Koji Uwai, Riho Taguchi, Kazuaki Chayama, Takemasa Sakaguchi, Ryo Narita, Wan-Ling Yao, Fumihiko Takeuchi, Yukie Otakaki, Koichi Watashi, Takaji Wakita, Hiroki Kato, Takashi Fujita ，PLOS ONE，13巻，5号，(頁 e0197664 ～ )，2018年05月

    

23. Structure-activity relations of rosmarinic acid derivatives for the amyloid beta aggregation inhibition and antioxidant properties

    Taguchi Riho, Hatayama Koki, Takahashi Tomohito, Hayashi Takafumi, Sato Yuki, Sato Daisuke, Ohta Kiminori, Nakano Hiroto, Seki Chigusa, Endo Yasuyuki, Tokuraku Kiyotaka, Uwai Koji，EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY，138巻，(頁 1066 ～ 1075)，2017年09月

    

24. Hybrid-Type Squaramide-Fused Amino Alcohol Organocatalysts for Enantioselective Diels–Alder Reactions of 3-Hydroxy-2-Pyridones with Maleimides

    Madhu Chennapuram, U. V. Subba Reddy, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita and Hiroto Nakano，European Journal of Organic Chemistry，2017巻，(頁 4633 ～ 4641)，2017年08月

    

25. A Diamino Alcohol Catalyzed Enantioselective Crossed Aldol Reaction of Acetaldehyde with Isatins – A Concise Total Synthesis of Antitumor Agents

    U. V. S. Reddy, M. Chennapuram, K. Seki, C. Seki, B. Anusha, E. Kwon, Y. Okuyama, K. Uwai, M. Tokiwa, M. Takeshita, H. Nakano，European Journal of Organic Chemistry，2017巻，(頁 3874 ～ 3885)，2017年07月

    

26. Hybrid-Type Squaramide-Fused Amino Alcohol Organocatalysts for Enantioselective Nitro-Aldol Reaction of Nitromethane with Isatins

    Chennapuram Madhu, Reddy U. V. Subba, Seki Chigusa, Okuyama Yuko, Kwon Eunsang, Uwai Koji, Tokiwa Michio, Takeshita Mitsuhiro, Nakano Hiroto，EUROPEAN JOURNAL OF ORGANIC CHEMISTRY，12号，(頁 1638 ～ 1646)，2017年03月

    

27. Simultaneous analysis of major ingredients of Gardenia fruit by HPLC-MS/TQMS method

    M Galaqin, K Uwai, M Yuguchi, T Iwasa，Mongolian J. Chem.，17巻，(頁 34 ～ 37)，2016年12月

    

28. Simple primary β-amino alcohol catalyzed enantioselective Diels-Alder reaction of 3-hydroxy-2-pyridones

    Toshihisa Takahashi, U.V. Subba Reddy, Yoshihito Kohari, Chigusa Seki, Taniyuki Furuyama, Nagao Kobayashi, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano，Tetrahedron Letters，57巻，51号，(頁 5771 ～ 5776)，2016年11月

    

29. 2-Azanorbornane-based amine organocatalyst for enantioselective aldol reaction of isatins with ketones

    Ayumi Ogasawara, U.V. Subba Reddy, Chigusa Seki, Yuko Okuyama, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano，Tetrahedron: Asymmetry，27巻，20-21号，(頁 1062 ～ 1068)，2016年09月

    

30. Simple Primary Amino Amide Organocatalyst for Enantioselective Aldol Reactions of Isatins with Ketones

    Jo Kimura, Ummareddy Venkata Subba Reddy, Yoshihito Kohari, Chigusa Seki, Yasuteru Mawatari, Koji Uwai, Yuko Okuyama, Eunsang Kwon, Michio Tokiwa, Mitsuhiro Takeshita, Tatsuo Iwasa and Hiroto Nakano， European Journal of Organic Chemistry，2016巻，(頁 3748 ～ 3756)，2016年07月

    

31. Lipase-Catalyzed Domino Michael-Aldol Reaction of 2-Methyl-1,3-Cycloalkanedione and Methyl Vinyl Ketone for the Synthesis of Bicyclic Compounds

    K. Sano, Y. Kohari, H. Nakano, C. Seki, M. Takeshita, M. Tokiwa, Y. Hirose, K. Uwai，Synthetic Communications，46巻，1号，(頁 46 ～ 54)，2016年01月

    

32. Chiral primary amino alcohol organobase catalysts for the asymmetric Diels-Alder reactionsof anthrones with maleimides

    1. J. Kumagai, T. Otsuki, U. V. Subba Reddy, Y. Kohari, C. Seki, K. Uwai, Y. Okuyama, E. Kwon, M. Tokiwa, M. Takeshita, H. Nakano，Tetrahedron: Asymmetry，26巻，24号，(頁 1423 ～ 1439)，2015年12月

    

33. Silyloxy Amino Alcohol Organocatalyst for Enantioselective 1,3-Dipolar Cycloaddition of Nitrones to α,β- Unsaturated Aldehydes

    A. T. Otsuki, J. Kumagai, Y. Kohari, Y. Okuyama, E. Kwon, C. Seki, K. Uwai, Y. Mawatari, N. Kobayashi, T. Iwasa, M. Tokiwa, M. Takeshita, A. Maeda, A. Hashimoto, K. Turuga, H. Nakano，Eur. J. Org. Chem.，2015巻，33号，(頁 7292 ～ 7300)，2015年11月

    

34. Evaluation of the effects of amyloid<beta>aggregation from seaweed extracts by a microliter-scale high-throughput screening system with a quantum dot nanoprobe

    T. Ogara, T. Takahashi, H. Yasui,K. Uwai, K. Tokuraku，J. Biosci. Bioeng.，120巻，1号，(頁 45 ～ 50)，2014年12月

    

35. Chiral Primary Amino Amide Alcohol Organocatalyst for the Asymmetric Michael Addition of 4-Hydroxycoumarinwith α,β-Unsaturated Ketones

    J. Kumagai, Y. Kohari, C. Seki, K. Uwai, Y. Okuyama, E. Kwon, H. Nakano，Heterocycles，90巻，2号，(頁 1124 ～ 1134)，2014年12月

    

36. Biotransformation of organic compounds in vivo using larvae of beetles (Allomyrina dichotoma) as biocatalysts

    K. Uwai, Y. Okuyama, H. Nakano,, K. Furukawa, E. Hiroshima, H. Azuma, M. Watanabe, T. Matsumoto, M. Tokiwa, M. Takeshita，Biocat. Agric. Biotech，3巻，(頁 129 ～ 133)，2014年09月

    

37. Enantioselective Diels-Alder Reaction of 1,2-Dihydropyridines with Aldehydes using beta-Amino Alcohol Organocatalyst

    Y. Kohari, Y. Okuyama, E. Kwon, T. Furuyama, N. Kobayashi, T. Otuki, J. Kumagai, C. Seki, K. Uwai, G. Dai, T. Iwasa, H. Nakano，J. Org. Chem.，79巻，20号，(頁 9500 ～ 9511)，2014年09月

    

38. Chiral Primary Amino Amide Alcohol Organocatalyst for the Asymmetric Michael Addition of 4-Hydroxycoumarin with α,β-Unsaturated Ketones

    J. Kumagai, Y. Kohari, C. Seki, K. Uwai, Y. Okuyama, E. Kwon, H. Nakano，Heterocycles，90巻，2号，(頁 1124 ～ 1134)，2014年09月

    

39. A Microliter-scale High-throughput Screening System with Quantum-dot Nanoprobes for Amyloid-β aggregation Inhibitors

    Y. Ishigaki, H. Tanaka, H. Akama, T. Ogara, K. Uwai, K. Tokuraku，PLoS ONE，8巻，8号，(頁 e72992 ～ )，2013年08月

    

40. Development of a novel method for warfarin synthesis via lipase-catalyzed stereoselective Michael reaction

    K. Sano, S. Saito, Y. Kohari, H. Nakano, Y. Hirose, M. Tokiwa, M. Takeshita, K. Uwai，Heterocycles，87巻，6号，(頁 1269 ～ 1278)，2013年05月

    

41. Compatibility of heparin sodium in intravenous line with nicardipine injected from a side tube via T-shape stopcock

    T. Hayashi, K. Uwai, E. Sasaki, K. Sasaki, Y. Iwabuchi, H. Agatsuma, T. Suzuki，医療薬学，38巻，11号，(頁 679 ～ 687)，2012年11月

    

42. Chiral Primary Amino Silyl Ether Organocatalyst for the Enantioselective Diels-Alder Reaction of 1,2-Dihydropyridines with Aldehydes

    Y. Sakuta, Y. Kohari, N. D. M. R. Hutabarat, K. Uwai, E. Kwon, Y. Okuyama, C. Seki, H. Matsuyama, N. Takano, M. Tokiwa, M. Takeshita, H. Nakano*，Heterocycles，86巻，2号，(頁 1379 ～ 1389)，2012年08月

    

43. Highly Enantioselective Synthesis of Isoquinuclidine by Diels-Alder Reaction of 1,2-Dihydropyridine Utilizing Chiral Bisoxazoline-Cu(II) Complex

    N. D. M. R. Hutabarat, C. Seki, T. Shimizu, M. Hirama, Y. Kohari, H. Nakano, K. Uwai,N.Takano, E. Kwon, H. Matsuyama，Heterocycles，86巻，1号，(頁 203 ～ 217)，2012年06月

    

44. Asymmetric synthesis of isoquinuclidines by Dielse-Alderreaction of 1,2-dihydropyridine utilizing a chiral Lewis acid catalyst

    C. Seki, M. Hirama, N.D.M. R. Hutabarat, J. Takada, C. Suttibut, H. Takahashi, T. Takaguchi, Y. Kohari, H. Nakano, K. Uwai, N. Takano, M. Yasui, Y. Okuyama, M. Takeshita, H. Matsuyama，Tetrahedron，68巻，6号，(頁 1774 ～ 1781)，2012年02月

    

45. One Step Synthesis of Optically Active Diazabicyclo[3.3.0]octanones or Diazabicyclo[4.3.0]nonanones by Asymmetric Conjugate Addition of Cyclic Hydrazine

    C. Seki, M. Hirama, T. Sato, S. Takeda, Y. Kohari, K. Ishigaki, M. Ohuchi, K. Yokoi, H. Nakano, K. Uwai, N. Takano, K. Umemura, H. Matsuyama，Heterocycles，85巻，5号，(頁 1045 ～ 1052)，2012年02月

    

46. Asymmetric Synthesis of Isoquinuclidine by Diels-Alder Reaction of 1,2-Dihydropyridine and Chiral Dienophile Utilizing a Chiral Lewis Acid

    M. Hirama, C. Suttibut, N. D. M. R. Hutabarat, C. Seki, N. Sakuta, T. Tsuchiya, Y. Kohari, H. Nakano, K. Uwai, N. Takano, M. Yasui, Y.Okuyama, K. Osone, M. Takeshita, H. Matsuyama，Heterocycles，84巻，1号，(頁 377 ～ 384)，2012年01月

    

47. A highly enantioselective Diels-Alder reaction of 1,2-dihydropyridine using a simple β-amino alcohol organocatalystfor a practical synthetic methodology of oseltamivir intermediate

    C. Suttibut, Y. Kohari, K. Igarashi, H. Nakano, M. Hirama, C. Seki, H. Matsuyama, , K. Uwai, N. Takano, Y. Okuyama, K. Osone, M. Takeshita, E. Kwon，Tetrahedron Letters，52巻，37号，(頁 4745 ～ 4748)，2011年09月

    

48. ロキソプロフェンナトリウム錠後発医薬品の単回投与での臨床効果

    吉川真一，鈴木美，村田亮，吉田進，上井幸司，鈴木常義、竹下光弘，ペインクリニック，31巻，5号，(頁 635 ～ 640)，2010年05月

    

49. Evaluation of Correlation between Dissolution Rates of Loxoprofen Tablets and Their Surface Morphology Observed by Scanning Electron Microscope and Atomic Force Microscope

    S. Yoshikawa, R. Murata, S. Shida, K. Uwai, T. Suzuki, S. Katsumata M. Takeshita，Chemical and Pharmaceutical Bulletin，58巻，1号，(頁 34 ～ 37)，2010年01月

    

50. Development of Clinical Application for a Nutritional Prescription Support System for Total Parenteral/Enteral Nutrition

    S. Masuda, R. Oka, K. Uwai, Y. Matsuda, T. Shiraishi, Y. Nakagawa, T. Shoji, C. Mihara, M. Takeshita, K. Ozawa，薬学雑誌，129巻，9号，(頁 1077 ～ 1086)，2009年09月

    

51. Reactivity and efficient recycling of achiral Pd-BINAP catalyst for catalytic asymmetric Diels-Alder reaction in ionic liquid

    Y. Nishiuchi, H. Nakano, Y. Araki, R Sato, R. Fujita, K. Uwai, M. Takeshita，Heterocycles，77巻，2号，(頁 1323 ～ 1331)，2009年02月

    

52. Organocatalytic activity of 4-hydroxy-prolinamide alcohol with different noncovalent coordination sites in asymmetric Michael and direct aldol reactions

    Yuko Okuyama, Hiroto Nakano, Yuki Watanabe, Mika Makabe, Mitsuhiro Takeshita, Koji Uwai, Chizuko Kabuto, Eunsang Kwon，Tetrahedron Letters，50巻，2号，(頁 193 ～ 197)，2009年01月

    

53. Trimidox-induced apoptosis is mediated through induction of p53 in NALM-6 cells.

    S. Kanno, T. Ohtake, Y. Osanai, K. Kurauchi, M. Ujibe, K. Uwai, M. Takeshita, S. Satoh, M. Ishikawa.，Journal of Pharmacological Sciences，106巻，3号，(頁 521 ～ 524)，2008年09月

    

54. Inhibitory Effect of the Alkyl Side Chain of Caffeic Acid Analogues on Lipopolysaccharide-induced Nitric Oxide Production in RAW264.7 Macrophages

    K. Uwai, Y. Osanai, T. Imaizumi, S. Kanno, M. Takeshita, M. Ishikawa，Bioorganic and Medicinal Chemistry，16巻，16号，(頁 7795 ～ 7803)，2008年08月

    

55. Inhibitory Effect of Octylcaffeate on Lipopolysaccharaide-Induced Nitric Oxide Production in Macrophages

    Y. Osanai, S. Kanno, K. Uwai, M. Takeshita, M. Ishikawa，応用薬理，75巻，1/2号，(頁 19 ～ 24)，2008年02月

    

56. Electronic effects of substituon on acetophenones in the reaction of rat liver 3alpha-hydroxysteroid dehydrogenase

    K. Uwai, N. Konno, Y. Yasuta, and M. Takeshita，Bioorganic and Medicinal Chemistry，16巻，3号，(頁 1084 ～ 1089)，2008年02月

    

57. Chiral cationic Pd-phosphinooxazolidine catalysts for a highly efficient asymmetric diels-alder reaction in ionic liquids.

    H. Nakano, Y. Nishiuchi, T. Takahashi, R.Fujita,K. Uwai, M. Takeshita，Heterocycles，76巻，1号，(頁 381 ～ 390)，2008年01月

    

58. Stability of Magnesium Oxide Products Kept in Single-dose Packages

    R. Oka，K. Uwai, T. Toyoguchi, T.i Shiraishi, Y. Nakagawa, M. Takeshita，医療薬学，33巻，12号，(頁 1013 ～ 1019)，2007年12月

    

59. Inhibitory effect of trimidox on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages.

    S. Kanno, K. Kakuta, Y. Kitajima, Y. Osanai, K. Kurauchi, T. Ohtake, M. Ujibe, K. Uwai, M. Takeshita, M. Ishikawa，Journal of Pharmacological Sciences，104巻，3号，(頁 278 ～ 281)，2007年09月

    

60. Preventive effect of trimidox on oxidative stress inU937 cell line.

    S. Kanno, M. Kakuta, Y. Kitajima,Y. Osanai, K. Kurauchi, T. Ohtake, M. Ujibe, K. Uwai, M. Takeshita, M. Ishikawa，Biological and Pharmaceutical Bulletin，30巻，5号，(頁 994 ～ 998)，2007年05月

    

61. Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukemia cells.

    S. Kanno, K. Uwai, A. Tomizawa, T. Hiura, Y. Osanai, M. Ujibe, M. Takeshita, T. Ohtake, K. Kimura, M. Ishikawa，Basic and Clinical Pharmacology and Toxicology，98巻，1号，(頁 44 ～ 50)，2006年01月

    

62. Octylcaffeate induced apoptosis in human leukemia U937 cells.

    M. Ujibe, S. Kanno,Y. Osanai, K. Koiwai,T. Ohtake, K. Kimura, K. Uwai, M. Takeshita, M. Ishikawa，Biological and Pharmaceutical Bulletin，28巻，12号，(頁 2338 ～ 2341)，2005年12月

    

63. Photodegradation products of propranolol: the structures and pharmacological studies

    K. Uwai, M. Tani, Y. Ohtake, S. Abe,A. Maruko, T. Chiba, Y. Hamaya, Y. Ohkubo, M. Takeshita，Life Sciences，78巻，4号，(頁 357 ～ 365)，2005年12月

    

64. Purification and characterization of rat liver enzyme catalyzing stereoselective reduction of acetylpyridines.

    K. Uwai, N. Konno, S. Kitamura, S. Ohta, M. Takeshita，Chirality，17巻，8号，(頁 494 ～ 500)，2005年09月

    

65. ナフトピジル製剤の光安定性

    M. Takeshita, T. Chiba, K. Uwai, K. Hisamichi, N. Sasaki, Y. Hamaya，医療薬学，31巻，6号，(頁 464 ～ 469)，2004年06月

    

66. Syntheses and Receptor-Binding Study of Derivatives of the Opioid Antagonist Naltrexone

    K. Uwai, H. Uchiyama, S. Sakurada, C. Kabuto, M. Takeshita，Bioorganic and Medicinal Chemistry，12巻，2号，(頁 417 ～ 421)，2004年01月

    

67. Synthesis and Biological Activity of Photoactivatable N-Ras-Peptides and -Proteins

    M. Volkert, K. Uwai, A. Tebbe, B. Popkirova, M. Wagner, J.Kuhlmann, H. Waldmann，Journal of the American Chemical Society，125巻，42号，(頁 12749 ～ 12758)，2003年10月

    

68. Synthesis and Reduction of (S)-(-)-Nicotine-N’-Oxide and N,N’-Dioxides by Rat Liver S-9 Fraction

    K. Uwai, H. Sato, N. Kazakami, H. Matsuzaki, M. Takeshita，Arkivoc，2003巻，8号，(頁 211 ～ 219)，2003年09月

    

69. Photoactivatable synthetic Ras proteins:"baits"for the identification of plasma-membrane-bound binding partners of Ras.

    J. Kuhlmann, A. Tebbe, M. Volkert, M. Wagner, K. Uwai, H. Waldmann，Angewandte Chemie International Edition，41巻，14号，(頁 2546 ～ 2550)，2002年07月

    

70. Virol A, a toxic polyacetylenic alcohol of Cicuta virosa, inhibits the GABA-induced Cl-current in the rat hippocampal CA1 Neurons.

    K. Uwai, K. Ohashi, Y. Takaya, Y. Oshima, K. Furukawa, K. Yamagata, T. Ohmura, S. Okuyama，Brain Research，889巻，1-2号，(頁 174 ～ 180)，2001年01月

    

71. Exploring the StructuralBasis of Neurotoxicity in C17-Polyacetylenes Isolated from Water Hemlock

    K. Uwai, K. Ohashi, Y. Takaya, T. Ohta, T. Tadano, K. Kisara, K. Shibusawa, R. Sakakibara, Y. Oshima，Journal of Medicinal Chemistry，43巻，23号，(頁 4508 ～ 4515)，2000年11月

    

72. Absolute stereochemistry of cicutoxin and related toxic polyacetylenic alcohols from Cicuta virosa

    T. Ohta, K. Uwai, R. Kikuchi, S.Nozoe, Y. Oshima, K. Sasaki, F. Yoshizaki，Tetrahedron，55巻，41号，(頁 12087 ～ 12098)，1999年10月

    

73. New Type of Feburifugine Analogues, Bearing a Quinolizine Moiety, Show Potent Antimalarial Activity against Plasmodium Malaria Parasite

    Y. Takaya, H. Tasaka, T. Chiba, K. Uwai, M. Tanitsu, H.-S. Kim, Y. Wataya, M. Miura, M. Takeshita, Y. Oshima，Journal of Medicinal Chemistry，42巻，16号，(頁 3163 ～ 3166)，1999年08月

    

74. Syntheses and Stereochemical Assignment of Toxic C17-Polyacetylenic Alcohols, Virols A, B, and C, Isolated from Water Hemlock (Cicuta virosa)

    K. Uwai, Y. Oshima, T. Sugihara, T. Ohta，Tetrahedron，55巻，31号，(頁 9469 ～ 9480)，1999年07月

    

75. Enantio- and Diastereocontrolled Synthesis of Epibatidine Analogues

    K. Hiroya, K. Uwai, K Ogasawara，Chemical and Pharmaceutical Bulletin，43巻，5号，(頁 901 ～ 903)，1995年05月