Papers - Uwai Koji

1. 農場における植物の葉の蛍光分光測定装置

   中西陽菜、上井幸司、飯森俊文，分光研究，vol.73，(p.135 ～ 137)，2025.02

   

2. On-Site Evaluation of Constituent Content and Functionality of Perilla frutescens var. crispa Using Fluorescence Spectra

   Hidemichi Sano, Satoru Kawaguchi, Toshifumi Iimori , Masahiro Kuragano , Kiyotaka Tokuraku and Koji Uwai，Molecules，vol.28，Article Number:7199，2023.10

   

3. New boro amino amide organocatalysts for asymmetric cross aldol reaction of ketones with carbonyl compounds

   Zubeda Begum, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita and Hiroto Nakano，RSC Advances，vol.13，(2)，(p.888 ～ 894)，2023.01

   

4. Thiourea fused g-amino alcohol organocatalysts for asymmetric Mannich reaction of b-keto active methylene compounds with imines

   Miku Nomura, Zubeda Begum, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita and Hiroto Nakano，RSC Advances，vol.13，(6)，(p.3715 ～ 3722)，2023.01

   

5. Cultivation Factors That Affect Amyloid-β Aggregation Inhibitory Activity in Perilla frutescens var. crispa

   Keiya Shimamori, Tomohiko Nambu, Daiki Kawamata, Masahiro Kuragano, Naoki Nishishita, Toshifumi Iimori, Shinya Yamanaka, Koji Uwai, Kiyotaka Tokuraku，Foods，vol.12，Article Number:486，2023.01

   

6. Microwave-assisted synthesis and formation mechanism of fluorescent carbon dots from starch

   Hisahiko Shibata, Mina Abe, Kazuya Sato, Koji Uwai, Kiyotaka Tokuraku, Toshifumi Iimori，Carbohydrate Polymer Technologies and Applications，vol.3，Article Number:100218，2022.06

   

7. Chemical analysis of amyloid β aggregation inhibitors derived from Geranium thunbergii

   Kenji Kubo, Hikaru Watanabe, Hiroyuki Kumeta, Tomoyasu Aizawa, Chigusa Seki, Hiroto Nakano, Kiyotaka Tokuraku, Koji Uwai，Bioorganic & Medicinal Chemistry，vol.68，Article Number:116840，2022.05

   

8. New small gamma-turn type N-primary amino terminal tripeptide organocatalyst for solvent-free asymmetric aldol reaction of various ketones with aldehydes

   Rajkumar Thiyagarajan, Zubeda Begum, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano，RSC Advances，vol.11，(61)，(p.38925 ～ 38932)，2021.12

   

9. Simple amino silyl ether organocatalyst for asymmetric hetero Diels–Alder reaction of isatins with enones

   Perumalsamy Parasuraman, Divakar Ganesan, Zubeda Begum, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano，CHIRALITY，vol.33，(8)，(p.454 ～ 464)，2021.08

   

10. Farm use of calcium hydroxide as an effective barrier against pathogens

    Shinji Matsuzaki, Kento Azuma, Xuguang Lin, Masahiro Kuragano, Koji Uwai, Shinya Yamanaka, Kiyotaka Tokuraku，Scientific Reports，vol.11，Article Number:7941，2021.04

    

11. Simple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes

    Zubeda Begum, Haruka Sannabe, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita and Hiroto Nakano，RSC Advances，(1)，(p.203 ～ 209)，2020.12

    

12. Daurichromenic Acid from the Chinese Traditional Medicinal Plant Rhododendron dauricum Inhibits Sphingomyelin Synthase and Aβ Aggregation

    Hadya Virupaksha Deepak, Mahadeva M. Swamy, Yuta Murai, Yoshiko Suga, Masaki Anetai, Takuro Yo, Masahiro Kuragano, Koji Uwai, Kiyotaka Tokuraku, Kenji Monde，Molecules，vol.25，Article Number:4077，2020.09

    

13. Evaluation of amyloid β42 aggregation inhibitory activity of commercial dressings by a microliter-scale high-throughput screening system using quantum-dot nanoprobes

    Masahiro Kuragano, Wataru Yoshinari, Xuguang Lin, Keiya Shimamori, Koji Uwai and Kiyotaka Tokuraku，Foods，vol.9，Article Number:825，2020.06

    

14. Design of calcium hydroxide–based granules for livestock sanitation

    Shinya Yamanaka, Shuya Hirano, Koji Uwai, Kiyotaka Tokuraku，Case Studies in Chemical and Environmental Engineering，vol.2，Article Number:100005，2020.04

    

15. Simple organocatalyst component system for asymmetric hetero Diels–Alder reaction of isatins with enones

    Perumalsamy Parasuraman, Zubeda Begum, Madhu Chennapuram, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita and Hiroto Nakano，RSC Advances，(10)，(p.17486 ～ 17491)，2020.04

    

16. Sugar Based γ-Amino Alcohol Organocatalyst for Asymmetric Michael Addition of β-Keto Esters with Nitroolefins

    Divakar Ganesan, Madhu Chennapuram, Zubeda Begum, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita, and Hiroto Nakano，Heterocycles，vol.98，(11)，(p.1536 ～ 1545)，2019.11

    

17. 2-Azanorbornane-Based Amino Alcohol Organocatalysts for Asymmetric Michael Reaction of β-Keto Esters with Nitroolefins

    Rei Togashi, Madhu Chennapuram, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano，European Journal of Organic Chemistry，vol.2019，(24)，(p.3882 ～ 3889)，2019.06

    

18. An automated microliter-scale high-throughput screening system (MSHTS) for real-time monitoring of protein aggregation using quantum-dot nanoprobes

    Sasaki, R., Tainaka, R., Ando, Y., Hashi, Y., Virupaksha D.H., Suga, Y., Murai, Y, Anetai, M., Monde, K., Ota, K., Ito, I., Kikuchi, H., Oshima, Y., Endo, Y., Nakao, H., Sakono, M., Uwai, K., and Tokuraku，Scientific Reports，vol.9，Article Number:2587，2019.02

    

19. Amino Amide Organocatalysts for Asymmetric Michael Addition of β-Keto Esters with β-Nitroolefins

    Isiaka A. Owolabi, Madhu Chennapuram, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano，BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN，vol.92，(3)，(p.696 ～ 701)，2019.01

    

20. A new type of amino amide organocatalyzed enantioselective crossed aldol reaction of ketones with aromatic aldehydes

    Isiaka A. Owolabi, U.V.Subba Reddy, Madhu Chennapuram, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano，Tetrahedron ，vol.74，(36)，(p.4705 ～ 4711)，2018.09

    

21. New Hybrid-type Squaramide-Fused Amino Alcohol Organocatalyst for Enantioselective Domino Michael Addition/Cyclization Reaction of Oxoindolines with Cyclic 1,3-Diketones

    Madhu Chennapuram, Isiaka Alade Owolabi, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita, and Hiroto Nakano，ACS OMEGA，vol.3，(9)，(p.11718 ～ 11726)，2018.09

    

22. Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction

    Yuta Tsukamoto, Sotaro Ikeda, Koji Uwai, Riho Taguchi, Kazuaki Chayama, Takemasa Sakaguchi, Ryo Narita, Wan-Ling Yao, Fumihiko Takeuchi, Yukie Otakaki, Koichi Watashi, Takaji Wakita, Hiroki Kato, Takashi Fujita ，PLOS ONE，vol.13，(5)，(p.e0197664 ～ )，2018.05

    

23. Structure-activity relations of rosmarinic acid derivatives for the amyloid beta aggregation inhibition and antioxidant properties

    Taguchi Riho, Hatayama Koki, Takahashi Tomohito, Hayashi Takafumi, Sato Yuki, Sato Daisuke, Ohta Kiminori, Nakano Hiroto, Seki Chigusa, Endo Yasuyuki, Tokuraku Kiyotaka, Uwai Koji，EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY，vol.138，(p.1066 ～ 1075)，2017.09

    

24. Hybrid-Type Squaramide-Fused Amino Alcohol Organocatalysts for Enantioselective Diels–Alder Reactions of 3-Hydroxy-2-Pyridones with Maleimides

    Madhu Chennapuram, U. V. Subba Reddy, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita and Hiroto Nakano，European Journal of Organic Chemistry，vol.2017，(p.4633 ～ 4641)，2017.08

    

25. A Diamino Alcohol Catalyzed Enantioselective Crossed Aldol Reaction of Acetaldehyde with Isatins – A Concise Total Synthesis of Antitumor Agents

    U. V. S. Reddy, M. Chennapuram, K. Seki, C. Seki, B. Anusha, E. Kwon, Y. Okuyama, K. Uwai, M. Tokiwa, M. Takeshita, H. Nakano，European Journal of Organic Chemistry，vol.2017，(p.3874 ～ 3885)，2017.07

    

26. Hybrid-Type Squaramide-Fused Amino Alcohol Organocatalysts for Enantioselective Nitro-Aldol Reaction of Nitromethane with Isatins

    Chennapuram Madhu, Reddy U. V. Subba, Seki Chigusa, Okuyama Yuko, Kwon Eunsang, Uwai Koji, Tokiwa Michio, Takeshita Mitsuhiro, Nakano Hiroto，EUROPEAN JOURNAL OF ORGANIC CHEMISTRY，(12)，(p.1638 ～ 1646)，2017.03

    

27. Simultaneous analysis of major ingredients of Gardenia fruit by HPLC-MS/TQMS method

    M Galaqin, K Uwai, M Yuguchi, T Iwasa，Mongolian J. Chem.，vol.17，(p.34 ～ 37)，2016.12

    

28. Simple primary β-amino alcohol catalyzed enantioselective Diels-Alder reaction of 3-hydroxy-2-pyridones

    Toshihisa Takahashi, U.V. Subba Reddy, Yoshihito Kohari, Chigusa Seki, Taniyuki Furuyama, Nagao Kobayashi, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano，Tetrahedron Letters，vol.57，(51)，(p.5771 ～ 5776)，2016.11

    

29. 2-Azanorbornane-based amine organocatalyst for enantioselective aldol reaction of isatins with ketones

    Ayumi Ogasawara, U.V. Subba Reddy, Chigusa Seki, Yuko Okuyama, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano，Tetrahedron: Asymmetry，vol.27，(20-21)，(p.1062 ～ 1068)，2016.09

    

30. Simple Primary Amino Amide Organocatalyst for Enantioselective Aldol Reactions of Isatins with Ketones

    Jo Kimura, Ummareddy Venkata Subba Reddy, Yoshihito Kohari, Chigusa Seki, Yasuteru Mawatari, Koji Uwai, Yuko Okuyama, Eunsang Kwon, Michio Tokiwa, Mitsuhiro Takeshita, Tatsuo Iwasa and Hiroto Nakano， European Journal of Organic Chemistry，vol.2016，(p.3748 ～ 3756)，2016.07

    

31. Lipase-Catalyzed Domino Michael-Aldol Reaction of 2-Methyl-1,3-Cycloalkanedione and Methyl Vinyl Ketone for the Synthesis of Bicyclic Compounds

    K. Sano, Y. Kohari, H. Nakano, C. Seki, M. Takeshita, M. Tokiwa, Y. Hirose, K. Uwai，Synthetic Communications，vol.46，(1)，(p.46 ～ 54)，2016.01

    

32. Chiral primary amino alcohol organobase catalysts for the asymmetric Diels-Alder reactions of anthrones with maleimides

    1. J. Kumagai, T. Otsuki, U. V. Subba Reddy, Y. Kohari, C. Seki, K. Uwai, Y. Okuyama, E. Kwon, M. Tokiwa, M. Takeshita, H. Nakano，Tetrahedron: Asymmetry，vol.26，(24)，(p.1423 ～ 1439)，2015.12

    

33. Silyloxy Amino Alcohol Organocatalyst for Enantioselective 1,3-Dipolar Cycloaddition of Nitrones to α,β- Unsaturated Aldehydes

    A. T. Otsuki, J. Kumagai, Y. Kohari, Y. Okuyama, E. Kwon, C. Seki, K. Uwai, Y. Mawatari, N. Kobayashi, T. Iwasa, M. Tokiwa, M. Takeshita, A. Maeda, A. Hashimoto, K. Turuga, H. Nakano，Eur. J. Org. Chem.，vol.2015，(33)，(p.7292 ～ 7300)，2015.11

    

34. Evaluation of the effects of amyloid<beta>aggregation from seaweed extracts by a microliter-scale high-throughput screening system with a quantum dot nanoprobe

    T. Ogara, T. Takahashi, H. Yasui,K. Uwai, K. Tokuraku，J. Biosci. Bioeng.，vol.120，(1)，(p.45 ～ 50)，2014.12

    

35. Chiral Primary Amino Amide Alcohol Organocatalyst for the Asymmetric Michael Addition of 4-Hydroxycoumarin with α,β-Unsaturated Ketones

    J. Kumagai, Y. Kohari, C. Seki, K. Uwai, Y. Okuyama, E. Kwon, H. Nakano，Heterocycles，vol.90，(2)，(p.1124 ～ 1134)，2014.12

    

36. Biotransformation of organic compounds in vivo using larvae of beetles (Allomyrina dichotoma) as biocatalysts

    K. Uwai, Y. Okuyama, H. Nakano,, K. Furukawa, E. Hiroshima, H. Azuma, M. Watanabe, T. Matsumoto, M. Tokiwa, M. Takeshita，Biocat. Agric. Biotech，vol.3，(p.129 ～ 133)，2014.09

    

37. Enantioselective Diels-Alder Reaction of 1,2-Dihydropyridines with Aldehydes using beta-Amino Alcohol Organocatalyst

    Y. Kohari, Y. Okuyama, E. Kwon, T. Furuyama, N. Kobayashi, T. Otuki, J. Kumagai, C. Seki, K. Uwai, G. Dai, T. Iwasa, H. Nakano，J. Org. Chem.，vol.79，(20)，(p.9500 ～ 9511)，2014.09

    

38. Chiral Primary Amino Amide Alcohol Organocatalyst for the Asymmetric Michael Addition of 4-Hydroxycoumarin with α,β-Unsaturated Ketones

    J. Kumagai, Y. Kohari, C. Seki, K. Uwai, Y. Okuyama, E. Kwon, H. Nakano，Heterocycles，vol.90，(2)，(p.1124 ～ 1134)，2014.09

    

39. A Microliter-scale High-throughput Screening System with Quantum-dot Nanoprobes for Amyloid-β aggregation Inhibitors

    Y. Ishigaki, H. Tanaka, H. Akama, T. Ogara, K. Uwai, K. Tokuraku，PLoS ONE，vol.8，(8)，(p.e72992 ～ )，2013.08

    

40. Development of a novel method for warfarin synthesis via lipase-catalyzed stereoselective Michael reaction

    K. Sano, S. Saito, Y. Kohari, H. Nakano, Y. Hirose, M. Tokiwa, M. Takeshita, K. Uwai，Heterocycles，vol.87，(6)，(p.1269 ～ 1278)，2013.05

    

41. Compatibility of heparin sodium in intravenous line with nicardipine injected from a side tubevia T-shape stopcock

    T. Hayashi, K. Uwai, E. Sasaki, K. Sasaki, Y. Iwabuchi, H. Agatsuma, T. Suzuki，Jpn. J. Pharm. Health Care Sci.,，vol.38，(11)，(p.679 ～ 687)，2012.11

    

42. Chiral Primary Amino Silyl Ether Organocatalyst for the Enantioselective Diels-Alder Reaction of 1,2-Dihydropyridines with Aldehydes

    Y. Sakuta, Y. Kohari, N. D. M. R. Hutabarat, K. Uwai, E. Kwon, Y. Okuyama, C. Seki, H. Matsuyama, N. Takano, M. Tokiwa, M. Takeshita, H. Nakano*，Heterocycles，vol.86，(2)，(p.1379 ～ 1389)，2012.08

    

43. Highly Enantioselective Synthesis of Isoquinuclidine by Diels-Alder Reaction of 1,2-Dihydropyridine Utilizing Chiral Bisoxazoline-Cu(II) Complex

    N. D. M. R. Hutabarat, C. Seki, T. Shimizu, M. Hirama, Y. Kohari, H. Nakano, K. Uwai,N.Takano, E. Kwon, H. Matsuyama，Heterocycles，vol.86，(1)，(p.203 ～ 217)，2012.06

    

44. Asymmetric synthesis of isoquinuclidines by Dielse-Alder reaction of 1,2-dihydropyridine utilizing a chiral Lewis acid catalyst

    C. Seki, M. Hirama, N.D.M. R. Hutabarat, J. Takada, C. Suttibut, H. Takahashi, T. Takaguchi, Y. Kohari, H. Nakano, K. Uwai, N. Takano, M. Yasui, Y. Okuyama, M. Takeshita, H. Matsuyama，Tetrahedron，vol.68，(6)，(p.1774 ～ 1781)，2012.02

    

45. One Step Synthesis of Optically Active Diazabicyclo[3.3.0]octanones or Diazabicyclo[4.3.0]nonanones by Asymmetric Conjugate Addition of Cyclic Hydrazine

    C. Seki, M. Hirama, T. Sato, S. Takeda, Y. Kohari, K. Ishigaki, M. Ohuchi, K. Yokoi, H. Nakano, K. Uwai, N. Takano, K. Umemura, H. Matsuyama，Heterocycles，vol.85，(5)，(p.1045 ～ 1052)，2012.02

    

46. Asymmetric Synthesis of Isoquinuclidine by Diels-Alder Reaction of 1,2-Dihydropyridine and Chiral Dienophile Utilizing a Chiral Lewis Acid

    M. Hirama, C. Suttibut, N. D. M. R. Hutabarat, C. Seki, N. Sakuta, T. Tsuchiya, Y. Kohari, H. Nakano, K. Uwai, N. Takano, M. Yasui, Y.Okuyama, K. Osone, M. Takeshita, H. Matsuyama，Heterocycles，vol.84，(1)，(p.377 ～ 384)，2012.01

    

47. A highly enantioselective Diels-Alder reaction of 1,2-dihydropyridine using a simple β-amino alcohol organocatalyst for a practical synthetic methodology of oseltamivir intermediate

    C. Suttibut, Y. Kohari, K. Igarashi, H. Nakano, M. Hirama, C. Seki, H. Matsuyama, , K. Uwai, N. Takano, Y. Okuyama, K. Osone, M. Takeshita, E. Kwon，Tetrahedron Letters，vol.52，(37)，(p.4745 ～ 4748)，2011.09

    

48. ロキソプロフェンナトリウム錠後発医薬品の単回投与での臨床効果

    吉川真一，鈴木美，村田亮，吉田進，上井幸司，鈴木常義、竹下光弘，Pain Clinic，vol.31，(5)，(p.635 ～ 640)，2010.05

    

49. Evaluation of Correlation between Dissolution Rates of LoxoprofenTablets and Their Surface Morphology Observed by Scanning Electron Microscope and Atomic Force Microscope

    S. Yoshikawa, R. Murata, S. Shida, K. Uwai, T. Suzuki, S. Katsumata M. Takeshita，Chemical and Pharmaceutical Bulletin，vol.58，(1)，(p.34 ～ 37)，2010.01

    

50. Development of Clinical Application for a Nutritional Prescription Support System for Total Parenteral/Enteral Nutrition

    S. Masuda, R. Oka, K. Uwai, Y. Matsuda, T. Shiraishi, Y. Nakagawa, T. Shoji, C. Mihara, M. Takeshita, K. Ozawa，Yakugaku Zasshi，vol.129，(9)，(p.1077 ～ 1086)，2009.09

    

51. Reactivity and efficient recycling of a chiral Pd-BINAP catalyst for catalytic asymmetric Diels-Alder reaction inionic liquid

    Y. Nishiuchi, H. Nakano, Y. Araki, R Sato, R. Fujita, K. Uwai, M. Takeshita，Heterocycles，vol.77，(2)，(p.1323 ～ 1331)，2009.02

    

52. Organocatalytic activity of 4-hydroxy-prolinamide alcohol with different noncovalent coordination sites in asymmetric Michael and direct aldol reactions

    Yuko Okuyama, Hiroto Nakano, Yuki Watanabe, Mika Makabe, Mitsuhiro Takeshita, Koji Uwai, Chizuko Kabuto, Eunsang Kwon，Tetrahedron Letters，vol.50，(2)，(p.193 ～ 197)，2009.01

    

53. Trimidox-induced apoptosis is mediated through induction of p53 in NALM-6 cells.

    S. Kanno, T. Ohtake, Y. Osanai, K. Kurauchi, M. Ujibe, K. Uwai, M. Takeshita, S. Satoh, M. Ishikawa.，Journal of Pharmacological Sciences，vol.106，(3)，(p.521 ～ 524)，2008.09

    

54. Inhibitory Effect of the Alkyl Side Chain of Caffeic Acid Analogues on Lipopolysaccharide-induced Nitric Oxide Production in RAW264.7 Macrophages

    K. Uwai, Y. Osanai, T. Imaizumi, S. Kanno, M. Takeshita, M. Ishikawa，Bioorganic and Medicinal Chemistry，vol.16，(16)，(p.7795 ～ 7803)，2008.08

    

55. Inhibitory Effect of Octylcaffeateon Lipopolysaccharaide-Induced Nitric Oxide Production inMacrophages

    Y. Osanai, S. Kanno, K. Uwai, M. Takeshita, M. Ishikawa，Pharmacometrics，vol.75，(1/2)，(p.19 ～ 24)，2008.02

    

56. Electronic effects of substituon onacetophenones in the reaction of rat liver 3alpha-hydroxysteroid dehydrogenase

    K. Uwai, N. Konno, Y. Yasuta, and M. Takeshita，Bioorganic and Medicinal Chemistry，vol.16，(3)，(p.1084 ～ 1089)，2008.02

    

57. Chiral cationic Pd-phosphinooxazolidine catalysts for a highly efficient asymmetric diels-alder reaction in ionic liquids.

    H. Nakano, Y. Nishiuchi, T. Takahashi, R.Fujita,K. Uwai, M. Takeshita，Heterocycles，vol.76，(1)，(p.381 ～ 390)，2008.01

    

58. Stability of Magnesium Oxide Products Keptin Single-dose Packages

    R. Oka，K. Uwai, T. Toyoguchi, T.i Shiraishi, Y. Nakagawa, M. Takeshita，Japanese Journal of Pharmaceutical Health Care and Sciences，vol.33，(12)，(p.1013 ～ 1019)，2007.12

    

59. Inhibitory effect of trimidox on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages.

    S. Kanno, K. Kakuta, Y. Kitajima, Y. Osanai, K. Kurauchi, T. Ohtake, M. Ujibe, K. Uwai, M. Takeshita, M. Ishikawa，Journal of Pharmacological Sciences，vol.104，(3)，(p.278 ～ 281)，2007.09

    

60. Preventive effect of trimidox on oxidative stress in U937 cell line.

    S. Kanno, M. Kakuta, Y. Kitajima,Y. Osanai, K. Kurauchi, T. Ohtake, M. Ujibe, K. Uwai, M. Takeshita, M. Ishikawa，Biological and Pharmaceutical Bulletin，vol.30，(5)，(p.994 ～ 998)，2007.05

    

61. Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukemia cells.

    S. Kanno, K. Uwai, A. Tomizawa, T. Hiura, Y. Osanai, M. Ujibe, M. Takeshita, T. Ohtake, K. Kimura, M. Ishikawa，Basic and Clinical Pharmacology and Toxicology，vol.98，(1)，(p.44 ～ 50)，2006.01

    

62. Octylcaffeate induced apoptosis in human leukemia U937 cells.

    M. Ujibe, S. Kanno,Y. Osanai, K. Koiwai,T. Ohtake, K. Kimura, K. Uwai, M. Takeshita, M. Ishikawa，Biological and Pharmaceutical Bulletin，vol.28，(12)，(p.2338 ～ 2341)，2005.12

    

63. Photodegradation products of propranolol: the structures and pharmacological studies

    K. Uwai, M. Tani, Y. Ohtake, S. Abe,A. Maruko, T. Chiba, Y. Hamaya, Y. Ohkubo, M. Takeshita，Life Sciences，vol.78，(4)，(p.357 ～ 365)，2005.12

    

64. Purification and characterization of rat liver enzyme catalyzing stereoselective reduction of acetylpyridines.

    K. Uwai, N. Konno, S. Kitamura, S. Ohta, M. Takeshita，Chirality，vol.17，(8)，(p.494 ～ 500)，2005.09

    

65. Photostability of Naftopidil

    M. Takeshita, T. Chiba, K. Uwai, K. Hisamichi, N. Sasaki, Y. Hamaya，Japanese Journal of PharmaceuticalHealth Care and Sciences，vol.31，(6)，(p.464 ～ 469)，2004.06

    

66. Syntheses and Receptor-Binding Study of Derivativesof the Opioid Antagonist Naltrexone

    K. Uwai, H. Uchiyama, S. Sakurada, C. Kabuto, M. Takeshita，Bioorganic and Medicinal Chemistry，vol.12，(2)，(p.417 ～ 421)，2004.01

    

67. Synthesis and Biological Activity of Photoactivatable N-Ras-Peptides and -Proteins

    M. Volkert, K. Uwai, A. Tebbe, B. Popkirova, M. Wagner, J.Kuhlmann, H. Waldmann，Journal of the American Chemical Society，vol.125，(42)，(p.12749 ～ 12758)，2003.10

    

68. Synthesisand Reduction of (S)-(-)-Nicotine-N'-Oxide and N,N'-Dioxides by Rat Liver S-9 Fraction

    K. Uwai, H. Sato, N. Kazakami, H. Matsuzaki, M. Takeshita，Arkivoc，vol.2003，(8)，(p.211 ～ 219)，2003.09

    

69. Photoactivatable synthetic Ras proteins:"baits"for the identification of plasma-membrane-bound binding partners of Ras.

    J. Kuhlmann, A. Tebbe, M. Volkert, M. Wagner, K. Uwai, H. Waldmann，Angewandte Chemie International Edition，vol.41，(14)，(p.2546 ～ 2550)，2002.07

    

70. Virol A, a toxic polyacetylenic alcohol of Cicuta virosa, inhibits the GABA-induced Cl-current in the rat hippocampal CA1 Neurons.

    K. Uwai, K. Ohashi, Y. Takaya, Y. Oshima, K. Furukawa, K. Yamagata, T. Ohmura, S. Okuyama，Brain Research，vol.889，(1-2)，(p.174 ～ 180)，2001.01

    

71. Exploring the Structural Basis of Neurotoxicity in C17-Polyacetylenes Isolated from Water Hemlock

    K. Uwai, K. Ohashi, Y. Takaya, T. Ohta, T. Tadano, K. Kisara, K. Shibusawa, R. Sakakibara, Y. Oshima，Journal of Medicinal Chemistry，vol.43，(23)，(p.4508 ～ 4515)，2000.11

    

72. Absolute stereochemistry of cicutoxin and related toxic polyacetylenic alcohols from Cicuta virosa

    T. Ohta, K. Uwai, R. Kikuchi, S.Nozoe, Y. Oshima, K. Sasaki, F. Yoshizaki，Tetrahedron，vol.55，(41)，(p.12087 ～ 12098)，1999.10

    

73. New Type of Feburifugine Analogues, Bearing a Quinolizine Moiety, Show Potent Antimalarial Activity against Plasmodium Malaria Parasite

    Y. Takaya, H. Tasaka, T. Chiba, K. Uwai, M. Tanitsu, H.-S. Kim, Y. Wataya, M. Miura, M. Takeshita, Y. Oshima，Journal of Medicinal Chemistry，vol.42，(16)，(p.3163 ～ 3166)，1999.08

    

74. Syntheses and Stereochemical Assignment of Toxic C17-Polyacetylenic Alcohols, Virols A, B, and C, Isolated from Water Hemlock (Cicuta virosa)

    K. Uwai, Y. Oshima, T. Sugihara, T. Ohta，Tetrahedron，vol.55，(31)，(p.9469 ～ 9480)，1999.07

    

75. Enantio- and Diastereocontrolled Synthesis of Epibatidine Analogues

    K. Hiroya, K. Uwai, K Ogasawara，Chemical and Pharmaceutical Bulletin，vol.43，(5)，(p.901 ～ 903)，1995.05