Personnel Information

写真a

Tokuraku Kiyotaka


Affiliation centers1, etc

Center of Environmental Science and Disaster Mitigation for Advanced Research

The master's program in charge

Division of Sustainable and Environmental Engineering

The doctoral program in charge

Division of Engineering

The department in charge

Department of Applied Sciences

Job title

Associate Professor

E-mail Address

E-mail address

Research field 【 display / non-display

  • Functional biochemistry

  • Biophysics

  • Chemical biology

Keywords for Research Field 【 display / non-display

  • amyloid

  • Alzheimer's Disease

  • actin

  • microtubule associated proteins

  • microtubule

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Research themes 【 display / non-display

  • Imaging of amyloid-beta peptide aggregation using a quantum dot-based nanoprobe

    amyloid,Quantum dot,Imaging,2008 ~ 2018

  • Functional analysis of microtubule-associated protein 4

    Microtubule,Microtubule-associated protein,Cytoskeleton,1996 ~ 2018

  • Conformation polymorphism and function of actin filament

    Actin,Myosin,Cofilin,1999 ~ 2018

Graduate school・Graduate course, etc. 【 display / non-display

  • University of Tsukuba

    1996.03,Master's Course,Graduate School, Division of Biosystem,バイオシステム専攻,Completed,Japan

  • Kyushu Institute of Technology

    1999.03,Doctoral program,Graduate School, Division of Information Engineering,Department of information science,Completed,Japan

Graduate school・major, etc. 【 display / non-display

  • Miyakonojo National College of Technology

    1992.03,その他,工業化学科,Graduate

  • Kyushu Institute of Technology

    1994.03,Faculty of Computer Science and Systems Engineering,生物化学システム工学科,Graduate,日本

Degree 【 display / non-display

  • PhD

    Study on the function of the pro-rich region in microtubule-associated protein 4

Academic Society 【 display / non-display

  • The Japanese Biochemical Society

  • The Zoological Society of Japan

  • The Biophysical Society of Japan

  • American Society for Biochemistry and Molecular Biology

  • Japan Society for Bioscience, Biotechnology, and Agrochemistry

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Academic prize 【 display / non-display

  • Outstanding Poster Award

    2014.11.10,The 5th Forum on Studies of the Environmental and Public Health Issues in the Asian Mega-cities (EPAM 2014)

  • Best Presentation Award

    2016.09.01,EPAM2016

  • Best Presentation Award

    2016.09.01,EPAM2016

  • Poster Award

    2017.10.24,he 10th International Conference and Exhibition on Nutraceuticals & Functional Foods

 

タンパク質の自己集合による機能創成

Purpose of Research

タンパク質が自己集合することにより創発される機能を解明する。

Summary of Research

アクチンフィラメント、微小管、アミロイドなど、繊維を形成するタンパク質について、その機能を調べる。
Research Content

Features / Benefits of Research

1.Point of research 2.Research of novelty
  • 自己集合制御機構の解明
  • アミロイドβ凝集阻害物質の微量ハイスループットスクリーニング(MSHTS)法を開発
3.Primacy of Technology 4.Situation of patent-related
  • 数μLの微量サンプル量で多数のサンプルのAβ凝集阻害活性を効率的に評価できる。また夾雑物を多く含む粗抽出物や食品の評価も可能。
 

Books 【 display / non-display

  • The Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery

    Taro Q.P. Uyeda, Kien Xuan Ngo, Noriyuki Kodera, Kiyotaka Tokuraku,Springer,Uni-directional Propagation of Structural Changes in Actin Filaments,(p.353),2018.06,978-9811084584

  • BIO Clinica

    徳樂清孝、上井幸司,北隆館,量子ドットを用いたAβ凝集阻害物質の微量ハイスループットスクリーニング法,(p.114),2016.04,0919-8237

  • NETT91

    徳樂清孝,北海道東北地域経済総合研究所,シソがつないだ地域連携 〜室蘭工業大学と北海道白糠町の包括連携協定による抗認知症物質の探索〜,(p.82),2016.01

  • Bionanoimaging, 1st Edition, Protein Misfolding&Aggregation

    Kiyotaka Tokuraku and Tsuneya Ikezu,Academic Press,Imaging of amyloid-β aggregation using a novel quantum dot nanoprobe and its advanced applications,(p.526),2013.11,9780123944313

  • Advances in Neurobiology, Cytoskeleton of the Nervous System

    Kiyotaka Tokuraku, Kazuyuki Matsushima, Hiroyuki Nakagawa, and Susumu Kotani,Springer,Microtubule-associated protein 4,(p.774),2011,978-1-4419-6786-2

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Papers 【 display / non-display

  • Structural insight into microtubule stabilization and kinesin inhibition by Tau family MAPs

    Hideki Shigematsu, Tsuyoshi Imasaki, Chihiro Doki, Takuya Sumi, Mari Aoki, Tomomi Uchikubo‑Kamo, Ayako Sakamoto, Kiyotaka Tokuraku, Mikako Shirouzu, and Ryo Nitta,J. Cell Biol.,Article Number:in press,2018.10

  • Unidirectional growth of heavy meromyosin (HMM) clusters along actin filaments revealed by real-time fluorescence microscopy

    Rika Hirakawa, Yusuke Nishikawa, Taro Q.P. Uyeda, Kiyotaka Tokuraku,Cytoskeleton,vol.74,(12),(p.482 ~ 489),2017.12

  • Structure-activity relations of rosmarinic acid derivatives for the amyloid beta aggregation inhibition and antioxidant properties

    Taguchi Riho, Hatayama Koki, Takahashi Tomohito, Hayashi Takafumi, Sato Yuki, Sato Daisuke, Ohta Kiminori, Nakano Hiroto, Seki Chigusa, Endo Yasuyuki, Tokuraku Kiyotaka, Uwai Koji,EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,vol.138,(p.1066 ~ 1075),2017.09

  • Allosteric regulation by cooperative conformational changes of actin filaments drives mutually exclusive binding with cofilin and myosin

    Ngo Kien Xuan, Umeki Nobuhisa, Kijima Saku T., Kodera Noriyuki, Ueno Hiroaki, Furutani-Umezu Nozomi, Nakajima Jun, Noguchi Taro Q. P., Nagasaki Akira, Tokuraku Kiyotaka, Uyeda Taro Q. P.,SCIENTIFIC REPORTS,vol.6,Article Number:35449,2016.10

  • Evaluation of the effects of amyloid beta aggregation from seaweed extracts by a microliter-scale high-throughput screening system with a quantum dot nanoprobe

    Ogara Toshiki, Takahashi Tomohito, Yasui Hajime, Uwai Koji, Tokuraku Kiyotaka,JOURNAL OF BIOSCIENCE AND BIOENGINEERING,vol.120,(1),(p.45 ~ 50),2015.07

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International conference proceedings 【 display / non-display

  • A microliter-scale high-throughput screening system of amyloid-β aggregation inhibitors

    Kiyotaka Tokuraku, Koji Uwai,The 26th Annual Meeting of International Congress on Nutrition and Integrative Medicine (ICNIM 2018),(p.22),2018.07,Sapporo

  • Real-time imaging of tau aggregation and evaluation of the aggregation inhibitors using a quantum-dot nanoprobe

    Reina Tainaka, Yurika Hashi, Hitomi Nakao, Kenji Kubo, Masafumi Sakono, Koji Uwai, and Kiyotaka Tokuraku,oint Seminar on Environmental Science and Disaster Mitigation Research 2018,(p.115 ~ 116),2018.03,Muroran

  • Isolation and characterization of amyloid-β aggregation inhibitors from native plants grown in Shiranuka town in Hokkaido

    Kenji Kubo, Hikaru Watanabe, Chigusa Seki, Hiroto Nakano, Kiyotaka Tokuraku and Koji Uwai,Joint Seminar on Environmental Science and Disaster Mitigation Research 2018,(p.111 ~ 112),2018.03,Muroran

  • Evaluation of inhibitory activity for amyloid-β aggregation of 162 species plants found in the Shiranuka area of eastern Hokkaido

    Hikaru Watanabe, Kenji Kubo, Koji Sugimura, Keiji Oba, Koji Uwai, and Kiyotaka Tokuraku,Joint Seminar on Environmental Science and Disaster Mitigation Research 2018,(p.47 ~ 48),2018.03,Muroran

  • Analysis of the mechanical properties of MAPs-bound microtubules using fluorescence microscope and mechanical chamber

    Miki Tamura, Kazufumi Matsui, Miyuki Siga, Arif Md. Rashedul Kabir, Akira Kakugo, Susumu Kotani, Kiyotaka Tokuraku,Joint Seminar on Environmental Science and Disaster Mitigation Research 2018,(p.45 ~ 46),2018.03,Muroran

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Research reports 【 display / non-display

  • 量子ドットナノプローブを用いたアミロイド凝集過程のリアルタイムイメージング技術とその活用

    徳樂清孝、上井幸司,第54回粉体に関する討論会講演論文集,(p.136 ~ 140),2016.09

  • 蛍光性半導体ナノ結晶を用いた高アルツハイマー剤の微量探索システムの開発

    徳樂清孝,モ・ルラン,(59),(p.6 ~ 8),2016.04

  • 量子ドットナノプローブを用いた香辛料からのβ-アミロイド凝集阻害物質の網羅的スクリーニング

    徳樂清孝,山崎香辛料振興財団 平成23年度助成金交付申請書,2012.04

  • 量子ドットナノプローブを用いた香辛料からのβ-アミロイド凝集阻害物質の網羅的スクリーニングについて

    徳樂清孝,Letters from MuroranIT,vol.43,2012.01

  • 共焦点顕微鏡を用いた微小管の単分子蛍光映像解析によるアルツハイマー病発症メカニズムの解明

    徳樂清孝,平成19年度「国立高等専門学校機構在外研究員」実績報告書,2009.04

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Presentaion at conference, meeting, etc. 【 display / non-display

  • 量子ドットナノプローブを用いたアミロイド凝集阻害物質の自動化スクリーニングシステムの開発

    佐々木里奈、安藤雄一、上井幸司、徳楽清孝,第91回日本生化学会大会,第91回日本生化学会大会オンライン要旨システム,2018.09.24,京都

  • 量子ドットを用いたTauリピートペプチド凝集阻害物質探索システムの開発と改良

    橋友理香、田井中玲奈、上井幸司、徳楽清孝,第91回日本生化学会大会,第91回日本生化学会大会オンライン要旨システム,2018.09.24,京都

  • 量子ドットナノプローブを用いたα-シヌクレイン凝集体のイメージング

    NUOMIN、野口太郎、徳楽清孝,第91回日本生化学会大会,第91回日本生化学会大会オンライン要旨システム,2018.09.24,京都

  • 量子ドットナノプローブを用いたtau凝集過程のリアルタイムイメージングと凝集阻害物質の活性評価

    田井中玲奈、橋友理香、中尾仁美、迫野昌文、徳楽清孝,第91回日本生化学会大会,第91回日本生化学会大会オンライン要旨システム,2018.09.24,京都

  • 微小管結合蛋白質が微小管の強度と曲がりやすさに与える影響

    田村水希、松井一史、Kabir Arif Md. Rashedul、角五彰、小谷享、徳楽清孝,第56回日本生物物理学会年会,第56回年会予稿集,(p.393-393),2018.09.15,岡山

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Patent and utility model acquisition 【 display / non-display

  • 常温溶融塩を用いた電気泳動法による希土類およびアルカリ土類元素の濃縮方法及び回収装置

    日本,4242313

  • アミロイドβタンパク質の凝集阻害用組成物

    日本,特願2015-249378,特開2016-124865

  • DISINFECTANT

    PCT,PCT/JP2016/057141,WO2016/143782

  • 消毒剤

    日本,特願2015-47017,特開2016-166150

  • 消毒用粒状散布剤

    日本,特願2016-176927

 

Class subject in charge 【 display / non-display

  • 生命科学

    2018,Department

  • 生化学B

    2018,Department

  • 生物工学実験(バイオシステムコース)

    2018,Department

  • 生物工学実験(応用化学コース)

    2018,Department

  • 基礎化学

    2018,Department

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Education paper 【 display / non-display

  • 高専型実践教育の可能性

    2007,徳楽清孝,生物物理,vol.47,(6), (p.397-401)